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Related Experiment Videos

Cannabinoid receptors and their endogenous agonists

C C Felder1, M Glass

  • 1Neuroscience Discovery, Eli Lilly Research Laboratory, Indianapolis, Indiana 46285, USA. felder@lilly.com

Annual Review of Pharmacology and Toxicology
|May 23, 1998
PubMed
Summary

Cannabinoid receptors, CB1 and CB2, have been identified and characterized. Research is advancing to understand the physiological roles of these marijuana-related receptors.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Cannabinoid receptors (CB1 and CB2) have been identified in the last decade.
  • Their signal transduction pathways and endogenous agonists are being elucidated.
  • Marijuana has a long history of therapeutic and recreational use.

Purpose of the Study:

  • To review the identification and characterization of cannabinoid receptor types.
  • To discuss the distribution and signaling of CB1 and CB2 receptors.
  • To highlight ongoing research into cannabinoid receptor function.

Main Methods:

  • Identification and characterization of two cannabinoid receptor types (CB1 and CB2).
  • Isolation of an endogenous lipid agonist from mammalian tissues.
  • Analysis of signal transduction pathways for both receptor types.

Main Results:

  • CB1 receptors are prevalent in brain neurons, modulating adenylate cyclase and ion channels.
  • CB2 receptors are located in immune cells, inhibiting adenylate cyclase.
  • Both receptors bind delta 9-THC from marijuana and the endogenous anandamide.

Conclusions:

  • Significant progress has been made in understanding cannabinoid receptor physiology.
  • Development of selective agonists, antagonists, genetic models, and antibodies will further elucidate receptor roles.
  • Further research is crucial for a comprehensive understanding of the cannabinoid system.

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