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Deep penetrating dermatofibroma

C L Laughlin1, P R Carrington

  • 1Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|May 23, 1998
PubMed
Summary
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Deep penetrating dermatofibroma is a rare skin tumor typically found on the lower extremities. Accurate histologic diagnosis is crucial to differentiate it from malignant conditions, preventing unnecessary treatment.

Area of Science:

  • Dermatopathology
  • Surgical Pathology

Background:

  • Deep penetrating dermatofibroma is an uncommon variant of dermatofibroma.
  • It characteristically affects the lower extremities of adult patients.

Observation:

  • A case of deep penetrating dermatofibroma was analyzed.
  • Histologic examination revealed a fibrohistiocytic neoplasm invading the subcutis with scalloped septal extensions.

Findings:

  • Immunohistochemical analysis showed positivity for Factor XIIIa.
  • CD34 staining was negative, aiding in differential diagnosis.

Implications:

  • Awareness of this entity is vital for dermatologic surgeons and pathologists.
  • Correct identification prevents over-treatment of a benign lesion.

Related Experiment Videos

  • Distinguishing it from dermatofibrosarcoma protuberans is critical based on histologic patterns.