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Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a
H Yoshikawa1, A Fujiyama, K Nakai
1Institute for Molecular and Cellular Biology, Osaka University, Japan.
Genomics
|May 23, 1998
Abstract:
Using a two-dimensional DNA mapping method, we detected four NotI restriction sites that escape chromosome X-specific methylation in humans. Two genes corresponding to two of these sites that lie in the region of Xp11.2-p11.4 were cloned and their properties studied. One of the genes matched a known gene, but the other, termed EXLM1, is novel and is predominantly expressed in cultured lymphocytes and skeletal muscle.