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Related Experiment Videos

Strain relatedness in persistent and recurrent candiduria

R Khatib1, O Ayeni, K M Riederer

  • 1Department of Medicine, St. John Hospital and Medical Center, Detroit, Michigan, USA.

The Journal of Urology
|May 23, 1998
PubMed
Summary

Strain relatedness analysis is not reliable for differentiating persistent versus recurrent candiduria. Most urinary Candida infections demonstrate strain persistence, suggesting a single organism causes prolonged or repeated episodes.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Genetics

Background:

  • Candiduria, a urinary tract infection caused by Candida species, can be persistent or recurrent.
  • Differentiating between persistent and recurrent candiduria is crucial for appropriate patient management and treatment strategies.

Purpose of the Study:

  • To evaluate the utility of determining strain relatedness in distinguishing between persistent and recurrent cases of candiduria.
  • To assess if genetic similarity of Candida isolates can reliably differentiate infection types.

Main Methods:

  • Prospective monitoring of patients diagnosed with candiduria over a 5-month period.
  • Genomic deoxyribonucleic acid (DNA) typing of paired Candida isolates using restriction endonuclease analysis with SfiI.
  • Isolates were deemed related if all DNA bands matched.

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Main Results:

  • Strain persistence was observed in 21 of 22 persistent candiduria cases and all 5 recurrent candiduria cases.
  • Paired Candida strains were genetically identical in 26 out of 27 patients analyzed.
  • Risk factors identified included antibiotic use, indwelling catheters, and diabetes mellitus.

Conclusions:

  • Strain persistence is a highly frequent occurrence in patients with candiduria.
  • Determining the strain relatedness of Candida urinary isolates is not a reliable method for differentiating persistent from recurrent infections.