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Related Experiment Videos

Effect of thyroid function on LDL oxidation

F Costantini1, S D Pierdomenico, D De Cesare

  • 1Centro per lo Studio dell'Ipertensione Arteriosa, dell Dislipidemie e dell'Arteriosclerosi, University Gabriele D'Annunzio, School of Medicine, Chieti, Italy.

Arteriosclerosis, Thrombosis, and Vascular Biology
|May 23, 1998
PubMed
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Thyroid disorders increase low-density lipoprotein (LDL) oxidation. Hyperthyroidism shows higher oxidation linked to thyroxine levels, while hypothyroidism has intermediate oxidation influenced by serum lipids.

Area of Science:

  • Endocrinology
  • Lipid Metabolism
  • Oxidative Stress

Background:

  • Thyroid hormones significantly influence metabolic activity.
  • Oxidative modification of low-density lipoprotein (LDL) is implicated in atherosclerosis.
  • The relationship between thyroid status and LDL oxidation requires further elucidation.

Purpose of the Study:

  • To investigate the impact of hyperthyroidism and hypothyroidism on LDL oxidation.
  • To assess the influence of thyroid hormone levels and metabolic state on LDL susceptibility to peroxidation.
  • To determine the correlation between specific antioxidants and LDL oxidation in different thyroid states.

Main Methods:

  • Assessed native LDL content of lipid peroxides, vitamin E, beta-carotene, and lycopene.

Related Experiment Videos

  • Evaluated LDL susceptibility to lipid peroxidation in hyperthyroid, hypothyroid, and control subjects.
  • Correlated LDL oxidation markers with free thyroxine and serum lipid levels.

    • Main Results:

    • Hyperthyroidism exhibited significantly higher LDL oxidation (increased lipid peroxides, lower lag phase, higher oxidation rate) compared to controls.
    • Hypothyroidism showed intermediate LDL oxidation, lower than hyperthyroidism but higher than controls.
    • Elevated LDL oxidation in hyperthyroidism correlated with higher free thyroxine levels; in hypothyroidism, it correlated with serum lipids.

    Conclusions:

    • Both hypothyroidism and hyperthyroidism are associated with increased LDL oxidation compared to normolipidemic individuals.
    • In hyperthyroidism, LDL oxidation is directly linked to free thyroxine levels.
    • In hypothyroidism, LDL oxidation is significantly influenced by serum lipid profiles.