[The effectiveness of in vitro fertilization. A cohort study of 300 couples]

A cohort of 300 couples, starting their first in-vitro fertilization (IVF) attempt between 1990 and 1992, were followed until completion of their treatment. A total of 897 treatment cycles were initiated. Of these 213 (23.7%) were cancelled, giving a total of 684 embryo replacements. One hundred and forty-one (47%) couples completed their treatment with delivery of at least one healthy baby. Ninety-eight (31.3%) couples completed their treatment without achieving delivery of a living baby, and 40 (13.7%) couples cancelled their treatment due to varying reasons. The treatment in seven couples was cancelled before completion due to medical reasons. In 12 women no transfer took place. IVF treatment is an effective procedure giving a "baby take home rate" of 47% within one to three cycles. A cohort study gives a realistic view of the probability of childbirth.