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Related Experiment Videos

Antihyperalgesic effects of spinal cannabinoids

J D Richardson1, L Aanonsen, K M Hargreaves

  • 1Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA.

European Journal of Pharmacology
|May 26, 1998
PubMed
Summary
This summary is machine-generated.

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Spinal cannabinoids become more effective at reducing thermal hyperalgesia during heightened pain states. This enhanced antihyperalgesic effect may stem from cannabinoids inhibiting neurosecretion from sensory neurons.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Cannabinoids are known to produce antinociception.
  • The effect of cannabinoids on thermal hyperalgesia is not well understood.
  • Drug potency can increase during hyperalgesia.

Purpose of the Study:

  • To investigate the effectiveness of intrathecal cannabinoids during hyperalgesia.
  • To determine if cannabinoids inhibit capsaicin-evoked neurosecretion.
  • To explore the role of cannabinoid receptors in sensory neurons.

Main Methods:

  • Administration of anandamide (intrathecal) in carrageenan-induced thermal hyperalgesia model.
  • Assessment of thermal latencies in normal and hyperalgesic animals.
  • Measurement of calcitonin gene-related peptide release from isolated rat spinal cord.

Related Experiment Videos

  • Identification of cannabinoid receptors in sensory neurons.

    • Main Results:

    • 1 fmol anandamide (intrathecal) completely blocked carrageenan-induced thermal hyperalgesia.
    • Anandamide did not affect thermal latencies in normal animals, even at high doses (100 pmol).
    • Anandamide inhibited both K+- and capsaicin-evoked calcitonin gene-related peptide release.
    • Cannabinoid receptors were found in sensory neurons.

    Conclusions:

    • Spinal cannabinoid effectiveness is increased during hyperalgesia.
    • Cannabinoids exhibit antihyperalgesic effects during heightened pain states.
    • This effect may be mediated by the inhibition of neurosecretion from primary afferent fibers.