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Variability of mitomycin C adsorption by activated charcoal
I A Shah1, W E Lindup, P G McCulloch
1Department of Pharmacology and Therapeutics, University of Liverpool, UK.
The Journal of Pharmacy and Pharmacology
|May 26, 1998
Summary
Mitomycin C adsorption on activated charcoal varies significantly with temperature, impacting drug delivery for gastric cancer treatment. Further research is needed to control these factors before clinical use.
Area of Science:
- Oncology
- Materials Science
- Pharmaceutical Sciences
Background:
- Mitomycin C adsorbed on activated charcoal shows promise for gastric carcinoma treatment.
- Activated charcoal targets tumors and lymph nodes, potentially increasing local drug concentration.
- Particle size variability in activated charcoal suspensions may affect drug adsorption and delivery, posing clinical risks.
Purpose of the Study:
- To investigate the in-vitro adsorption of mitomycin C on activated charcoal.
- To determine the impact of particle size and temperature on mitomycin C adsorption.
- To identify factors influencing the consistency of drug adsorption for clinical safety.
Main Methods:
- Activated charcoal was fractionated into four size ranges (180-53 microm).
- Mitomycin C adsorption isotherms were determined using HPLC (0-100 microg mL(-1)).
- Adsorption was studied at room temperature (21°C) and physiological temperature (37°C).
Main Results:
- Mitomycin C adsorption varied by a factor of three between room temperature and 37°C.
- Specific adsorption was generally higher at 37°C.
- Polyvinylpyrollidone addition reduced adsorption variability and indicated independence from particle size.
Conclusions:
- Mitomycin C adsorption on activated charcoal is temperature-dependent and complex.
- Variability in adsorption poses a clinical risk due to mitomycin C's narrow therapeutic index.
- Critical controlling factors must be identified before further clinical evaluation of these suspensions.