The calcium store in the nuclear envelope
O H Petersen1, O V Gerasimenko, J V Gerasimenko
1MRC Secretory Control Research Group, Physiological Laboratory, University of Liverpool, UK.
Abstract:
The nuclear envelope has a relatively small volume, but is connected up to the vastly larger endoplasmic reticulum. The Ca2+ concentration in the lumen of the interconnected nuclear envelope and endoplasmic reticulum network is in the resting state maintained at a level of more than 100 microM. There are specific Ca2+ release channels present in the inner nuclear membrane that can be activated by inositol trisphosphate or cADP ribose. The system, therefore, allows selective release of Ca2+ into the nucleoplasm which could be important for the control of specific types of gene expression.
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