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Leukemogenesis: small differences in Myb have large effects
1EMBL, Heidelberg, Germany. graf@embl-heidelberg.de
Current Biology : CB
|May 28, 1998
Abstract:
The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regulated.