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5-HT2A receptor gene promoter polymorphism--1438G/A and mood disorders
K Ohara1, M Nagai, T Tsukamoto
1Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.
Neuroreport
|May 28, 1998
Summary
The -1438G/A polymorphism in the serotonin 5-HT2A receptor gene was not associated with mood disorders in Japanese individuals. This finding suggests this specific genetic variation may not be a risk factor for mood disorders.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- The serotonin 5-HT2A receptor is implicated in mood regulation.
- A promoter polymorphism (-1438G/A) in the 5-HT2A receptor gene has been linked to anorexia nervosa.
- Mood disorders frequently co-occur with anorexia nervosa.
Purpose of the Study:
- To investigate the association between the 5-HT2A receptor -1438G/A polymorphism and mood disorders in a Japanese population.
Main Methods:
- Genotyping of the -1438G/A polymorphism.
- Comparison of allele and genotype frequencies between 95 Japanese patients with mood disorders and 106 healthy Japanese controls.
Main Results:
- No significant difference in allele frequency for the -1438G/A polymorphism was observed between patients and controls.
- Genotype frequencies did not vary based on mood disorder subdiagnosis, age of onset, family psychiatric history, or suicide attempts.
Conclusions:
- The 5-HT2A receptor -1438G/A polymorphism is not associated with mood disorders in the studied Japanese population.
- This genetic variation may not be a significant risk factor for the development of mood disorders.