Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T lymphocyte differentiation in the periphery

K M Murphy1

  • 1Howard Hughes Medical Institute, Washington University School of Medicine, Pathology Department, St Louis, MO 63110, USA. murphy@immunology.wustl.edu

Current Opinion in Immunology
|May 29, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Control of Common Bunt in Organic Wheat.

Plant disease·2019
Same author

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.

Oncogene·2017
Same author

Effect of varying the gas headspace to meat ratio on the quality and shelf-life of beef steaks packaged in high oxygen modified atmosphere packs.

Meat science·2013
Same author

Primary synovial sarcoma of the kidney. A case report with pathologic appraisal investigation and literature review.

Pathologica·2012
Same author

Neuroanatomic and behavioral traits for autistic disorders in age-specific restricted index selection mice.

Neuroscience·2011
Same author

Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group.

Cancer chemotherapy and pharmacology·2011
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Recent research clarifies how cytokine patterns in CD4+ T cells shape immune responses. Key findings include new insights into Interleukin-4 (IL-4) sources for Th2 immunity and Interferon-gamma (IFN-gamma) in Th1 development.

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • Immune response development is critically regulated by cytokine expression patterns in activated CD4+ T cells.
  • Understanding the cellular and molecular mechanisms governing T helper cell differentiation is crucial for immunology.
  • Recent advancements have shed light on the complexities of Th1 and Th2 cell development.

Purpose of the Study:

  • To summarize recent advancements in understanding cytokine expression patterns in CD4+ T cells.
  • To highlight new findings regarding the sources of Interleukin-4 (IL-4) and their role in T helper 2 (Th2) cell development.
  • To present new insights into T helper 1 (Th1) cell development, including the roles of Interleukin-12 (IL-12) receptors, Interferon-gamma (IFN-gamma), and Interleukin-18 (IL-18).

Main Methods:

Related Experiment Videos

  • Review of recent scientific literature and experimental findings.
  • Analysis of cellular and molecular mechanisms of T cell activation and differentiation.
  • Investigation of cytokine gene expression and regulation, including the IL-4 locus.

Main Results:

  • Identified potential sources of IL-4 contributing to Th2 immune responses against specific pathogens.
  • Provided insights into early immune responses and genetic factors influencing susceptibility in experimental murine Leishmaniasis.
  • Clarified the transcriptional regulation of the IL-4 gene locus.
  • Advanced the understanding of Th1 cell development through new data on IL-12 receptors.
  • Elucidated the mechanisms of IFN-gamma gene expression and the function of the novel cytokine IL-18.

Conclusions:

  • Recent progress has significantly enhanced our understanding of the molecular and cellular basis of T helper cell differentiation.
  • New discoveries regarding cytokine regulation and function offer potential targets for modulating immune responses.
  • Further research into genetic susceptibility and cytokine actions holds promise for developing novel therapeutic strategies for infectious diseases and immune disorders.