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Related Experiment Videos

Relation between left ventricular function and oxidative stress in patients undergoing bypass surgery

E De Vecchi1, M G Pala, G Di Credico

  • 1Department of Laboratory Medicine, IRCCS H San Raffaele, Milan, Italy.

Heart (British Cardiac Society)
|May 29, 1998
PubMed
Summary

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Preoperative left ventricular ejection fraction (LVEF) is linked to the heart's ability to manage oxidative stress during bypass surgery. A higher LVEF indicates a better capacity to counteract the oxidative burst after ischemia and reperfusion.

Area of Science:

  • Cardiology
  • Biochemistry
  • Surgical Research

Background:

  • Coronary bypass surgery involves periods of ischemia and reperfusion, leading to oxidative stress.
  • The heart's functional capacity, indicated by left ventricular ejection fraction (LVEF), may influence its response to this stress.

Purpose of the Study:

  • To investigate the relationship between preoperative left ventricular ejection fraction (LVEF) and the extent of myocardial oxidative stress during cardiopulmonary bypass surgery.

Main Methods:

  • An observational study involving 31 patients undergoing elective coronary bypass surgery.
  • Measurement of myocardial glutathione and adenine nucleotides from biopsies, and blood-derived markers of oxidative stress.
  • Assessment of coronary sinus-artery differences for glutathione, nucleotides, and lipid peroxidation products.

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Main Results:

  • Preoperative LVEF correlated significantly with myocardial glutathione and adenine nucleotide levels.
  • Increased release of oxidized glutathione during reperfusion was inversely correlated with LVEF.
  • Reduced glutathione and the glutathione redox ratio showed a direct correlation with LVEF, as did lipid peroxidation and post-operative CK-MB levels.

Conclusions:

  • The heart's ability to mitigate the oxidative stress following ischemia and reperfusion is associated with its functional capacity, as reflected by LVEF.