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Related Experiment Videos

Differential receptor usage by measles virus strains

R Bartz1, R Firsching, B Rima

  • 1Institut für Virologie und Immunbiologie, Würzburg, Germany.

The Journal of General Virology
|May 29, 1998
PubMed
Summary

Measles virus (MV) strains exhibit varied receptor usage. While some MV strains use CD46, others like WTFb utilize different cellular receptors, indicating strain-specific binding.

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Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Previous studies showed measles virus (MV) infection inhibition by CD46 antibodies, but not all strains downregulated CD46.
  • This research investigates differing MV strain interactions with CD46 and target cells.

Purpose of the Study:

  • To explore the distinct receptor usage of MV strains, specifically WTFb, WTFv, and Edmonston (Edm).
  • To understand the binding mechanisms of MV strains to CD46 and alternative cellular receptors.

Main Methods:

  • Comparing infection inhibition by CD46 antibodies across different MV strains (WTFb, WTFv, Edm).
  • Assessing the binding affinity of MV strain WTFb to CD46-expressing cells versus BJAB cells.
  • Evaluating the binding capacity of MV WTFb envelope glycoproteins to soluble CD46.

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Main Results:

  • MV strain WTFb infection is not inhibited by CD46 antibodies, unlike strain WTFv and Edm.
  • WTFb binds to cellular receptors on BJAB cells, not CD46-expressing CHO cells.
  • WTFb glycoproteins show limited binding to CD46, suggesting alternative receptor use.

Conclusions:

  • MV strain WTFb and Edm utilize distinct binding sites on human cells.
  • MV strains can use CD46 and/or an unknown molecule as receptors, depending on the strain.