Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic prophylaxis for permanent pacemaker implantation: a meta-analysis

A Da Costa1, G Kirkorian, M Cucherat

  • 1Service de Cardiologie, Hôpital cardiovasculaire et pneumologique, Lyon, France.

Circulation
|May 29, 1998
PubMed
Summary

Systemic antibiotic prophylaxis significantly reduces infection risk after permanent pacemaker implantation. This meta-analysis supports using antibiotics during pacemaker insertion to prevent serious complications like pocket infections and septicemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Head injury in older adults presenting to the ambulance service: who do we convey to the emergency department, and what clinical variables are associated with an intracranial bleed? A retrospective case-control study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2023
Same author

Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study.

PloS one·2022
Same author

Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis.

Thrombosis research·2020
Same author

[Evaluation of a support for the analysis of electrocardiogram by emergency residents].

Annales de cardiologie et d'angeiologie·2020
Same author

Secondary dengue infection in immunocompetent murine model leads to heart tissue damage.

Acta virologica·2019
Same author

Antibiotic prophylaxis of infective endocarditis in patients with predisposing cardiac conditions: French cardiologists' implementation of current guidelines.

International journal of cardiology·2019

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Device Technology

Background:

  • Infection is a significant risk following permanent pacemaker implantation.
  • Current practices often include antibiotic prophylaxis, but robust evidence is limited.

Purpose of the Study:

  • To evaluate the efficacy of antibiotic prophylaxis in reducing infection rates after permanent pacemaker implantation.
  • To synthesize data from randomized controlled trials on this topic.

Main Methods:

  • A meta-analysis was conducted on all available randomized trials.
  • Trials included patients undergoing permanent pacemaker implantation.
  • Inclusion criteria focused on systemic antibiotic use versus a control group, with infection as the primary endpoint.

Related Experiment Videos

Main Results:

  • Seven trials involving 2023 patients were analyzed.
  • The meta-analysis demonstrated a significant protective effect of antibiotic pretreatment (P=.0046).
  • Common odds ratio for infection was 0.256 (95% CI: 0.10 to 0.656).

Conclusions:

  • Systemic antibiotic prophylaxis significantly lowers the incidence of infections post-pacemaker implantation.
  • Prophylactic antibiotics are recommended at the time of pacemaker insertion.
  • This practice helps prevent short-term complications such as pocket infection, skin erosion, and septicemia.