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Interleukin-10 production during and after upper abdominal surgery
1Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Japan.
Journal of Clinical Anesthesia
|May 29, 1998
Summary
Major abdominal surgery significantly elevates plasma interleukin-10 (IL-10) levels, peaking 4 hours post-incision. These elevated IL-10 levels, linked to blood loss, suggest a role in modulating perioperative inflammation.
Area of Science:
- Immunology
- Surgical Science
- Anesthesiology
Background:
- Interleukin-10 (IL-10) is a key cytokine involved in immune regulation.
- The impact of major abdominal surgery on IL-10 plasma levels requires further elucidation.
Purpose of the Study:
- To investigate the perioperative changes in plasma levels of interleukin-10 (IL-10) following major abdominal surgery.
- To explore the correlation between IL-10 levels and intraoperative blood loss.
Main Methods:
- Prospective study involving 10 patients undergoing upper abdominal surgery.
- Combined general-epidural anesthesia was administered.
- Plasma IL-10, IL-6, and IL-8 levels were measured using ELISA at multiple perioperative time points.
Main Results:
- Plasma IL-10 was undetectable preoperatively but significantly elevated 4 hours after skin incision (p < 0.05).
- IL-10 levels returned to baseline by postoperative day 3.
- Peak IL-10 levels correlated significantly with intraoperative blood loss (r = 0.69, p < 0.05).
Conclusions:
- Major abdominal surgery leads to a significant increase in plasma IL-10 levels during and after the operation.
- IL-10 may play a role in modulating the inflammatory response in the perioperative period.