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The search for human obesity genes

A G Comuzzie¹, D B Allison

¹Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA. agcom@darwin.sfbr.org

Science (New York, N.Y.)

|June 20, 1998

Summary

Genetic factors significantly influence human obesity, with heritability estimates ranging from 40-70%. Identifying specific obesity genes is challenging due to complex gene-environment-behavior interactions. This article reviews current strategies and findings in human obesity genetics research.

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Area of Science:

Genetics
Obesity Research
Human Physiology

Background:

Human obesity is a complex trait with a significant heritable component, estimated at 40-70% of phenotypic variation.
While single-gene mutations cause obesity in animal models, human obesity is typically polygenic.
The interplay of multiple genes, environmental factors, and behavioral patterns complicates the identification of obesity-related genes in humans.

Purpose of the Study:

To discuss current strategies employed in the search for human obesity genes.
To highlight recent promising findings in the field of human obesity genetics.

Main Methods:

Review of genetic research methodologies for identifying obesity-associated genes.
Analysis of recent studies reporting significant genetic discoveries related to human obesity.

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Main Results:

Heritability of obesity-related phenotypes in humans is substantial (40-70%).
Human obesity commonly results from complex interactions among multiple genes, environmental influences, and behaviors.
Current research employs advanced strategies to overcome the challenges in identifying specific human obesity genes.

Conclusions:

The genetic architecture of human obesity is intricate, involving numerous genes and environmental interactions.
Ongoing research utilizing diverse strategies is crucial for advancing our understanding of obesity etiology.
Continued investigation into genetic influences is vital for developing effective obesity prevention and treatment strategies.