Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Helical superstructures from charged Poly(styrene)-Poly(isocyanodipeptide) block copolymers

Cornelissen1, Fischer, Sommerdijk

  • 1Department of Organic Chemistry, Nijmegen SON Research Center, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, the Netherlands.

Science (New York, N.Y.)
|June 5, 1998
PubMed
Summary

Chiral poly(isocyanide) block copolymers self-assemble into diverse structures like micelles and vesicles. These novel materials, featuring a poly(styrene) tail, offer tunable morphologies for advanced applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Centromeric satellite expansion drives genome evolution in the snowy owl.

Genome biology·2026
Same author

[M.K.R. II on dried blood by the Meinicke-Fischer technic].

Il Dermosifilografo·2014
Same author

Anaphylaxis of organs and transplants.

Praxis·2010
Same author

Hip reports.

Praxis·2010
Same author

Poliomyelitis, bulbar, encephalitic.

Archives of pediatrics·2010
Same author

3D imaging, planning, navigation.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy·2006

Area of Science:

  • Polymer Chemistry
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Amphiphilic block copolymers are versatile building blocks for self-assembly.
  • Chiral macromolecules offer unique structural and functional properties.

Purpose of the Study:

  • To synthesize and characterize novel amphiphilic block copolymers with charged helical poly(isocyanide) headgroups.
  • To investigate the self-assembly behavior and morphological control of these copolymers in aqueous systems.

Main Methods:

  • Synthesis of poly(styrene)-poly(isocyanide) block copolymers using peptide-derived isocyanides.
  • Characterization of self-assembled structures (micelles, vesicles, bilayer aggregates) using various techniques.
  • Exploration of factors influencing morphology, including block length, pH, and anion interactions.

Related Experiment Videos

Main Results:

  • Successful preparation of amphiphilic block copolymers with poly(styrene) and charged helical poly(isocyanide) blocks.
  • Demonstration of self-assembly into micelles, vesicles, and bilayer aggregates, analogous to surfactants.
  • Control over aggregate morphology achieved by tuning copolymer composition and environmental conditions (pH, anions).
  • Formation of helical superstructures with a helical sense opposite to the constituent block copolymers due to macromolecular chirality.

Conclusions:

  • Chiral poly(isocyanide) block copolymers exhibit tunable self-assembly into diverse morphologies.
  • These novel macromolecules present opportunities for applications in life sciences and materials science.
  • The ability to control structure and morphology from easily accessible peptide-derived units is a significant advancement.