Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activity and passive-avoidance learning in cobalt-injected rats

M Czarnota1, D Whitman, R Berman

  • 1University of Michigan, USA. dwhitman@sun.science.wayne.edu

The International Journal of Neuroscience
|May 30, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Rise of Supportive Oncology: A Revolution in Cancer Care.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

A comparison of lung cancer in HIV-positive and HIV-negative populations.

African journal of thoracic and critical care medicine·2022
Same author

Role of interventional radiology in pain management in oncology patients.

Clinical radiology·2022
Same author

Supportive Care: An Indispensable Component of Modern Oncology.

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same author

Global variations in the level of cancer-related research activity and correlation to cancer-specific mortality: Proposal for a global curriculum.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Global Variations in the Level of Cancer-Related Research Activity and Correlation to Cancer-Specific Mortality: Proposal for a Global Curriculum.

Annals of surgical oncology·2017
Same journal

Thoracic paravertebral nerve block combined with general anesthesia for patients undergoing minimally invasive vertebroplasty: effects on pain and lumbar function.

The International journal of neuroscience·2026
Same journal

Recurrence associated IGFBP2 promotes malignant progression and epithelial mesenchymal transition in glioma cells via the AKT mTOR pathway.

The International journal of neuroscience·2026
Same journal

Decreased miR-1305 expression is associated with tumour invasiveness and poor prognosis in glioma patients.

The International journal of neuroscience·2026
Same journal

Astaxanthin alleviates ischemia-reperfusion injury by regulating the JAK2/STAT3 signaling pathway.

The International journal of neuroscience·2026
Same journal

Clinical efficacy of cryopreserved autologous bone flaps versus titanium plates for cranioplasty: a retrospective comparative study.

The International journal of neuroscience·2026
Same journal

Sericin improves diabetic cognitive impairment in rats by inhibiting TXNIP/NLRP3 neuroinflammation through SIRT1.

The International journal of neuroscience·2026
See all related articles

Cobalt exposure in rats led to reduced exploratory behavior and impaired passive avoidance learning. Further research is needed to understand cognitive-behavioral effects of cobalt toxicity.

Area of Science:

  • Neuroscience
  • Toxicology
  • Behavioral Science

Background:

  • Hard metal disease in humans is linked to cognitive-behavioral deficits.
  • Cobalt, a component of hard metals, is a known toxic substance.
  • Understanding cobalt's neurotoxic effects is crucial for occupational health.

Purpose of the Study:

  • To investigate the cognitive-behavioral effects of cobalt exposure in a rat model.
  • To assess the impact of cobalt on learning and memory functions.
  • To identify potential dose-dependent effects of cobalt exposure.

Main Methods:

  • Rats were exposed to varying doses of cobalt.
  • Exploratory behavior was measured.
  • Passive avoidance learning and active maze learning tasks were performed.

Related Experiment Videos

  • Behavioral changes were analyzed in relation to cobalt dosage.

    • Main Results:

    • Cobalt exposure significantly decreased exploratory behavior in rats.
    • A trend towards decreased passive avoidance learning was observed in higher-dose groups.
    • No significant alterations in active maze learning were detected.
    • Results suggest a specific impact on certain cognitive functions.

    Conclusions:

    • Cobalt exposure can induce cognitive-behavioral deficits, including impaired learning.
    • Further research is warranted to elucidate the mechanisms of cobalt neurotoxicity.
    • Methodological considerations are important for future studies on cobalt's behavioral effects.