The effects of cadmium and experimental diabetes on VEP spectral data and lipid peroxidation

Fifty-two healthy swiss male albino rats, aged three months were used in this study. They were divided into four groups: Control (C), diabetic (D), Cadmium (Cd) and diabetic + Cadmium (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 i.p. (2 mg/kg/week). At the end of the two months of experimental period, flash visual evoked potentials (FVEPs) of four groups were recorded and amplitude spectral analysis was computed by transient response-frequency characteristics (TRFC) method. Significant amplitude decrement was found in 2-4 Hz frequency band of D + Cd group in comparison with C group. On the other hand, our data showed that Cd treatment and diabetic condition caused a significant increase of lipid peroxidation in kidney, brain, retina and lens.