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Related Experiment Videos

Clinical practice--breath tests

G D Bell1

  • 1Gastroenterology Department, Sunderland District General Hospital, UK.

British Medical Bulletin
|May 30, 1998
PubMed
Summary
This summary is machine-generated.

The urea breath test detects Helicobacter pylori infection by measuring labeled carbon dioxide in breath. This non-invasive method is effective for monitoring treatment success and studying infection dynamics.

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Area of Science:

  • Medical diagnostics
  • Microbiology
  • Gastroenterology

Background:

  • Helicobacter pylori (H. pylori) infection is a common cause of gastrointestinal issues.
  • Accurate diagnostic methods are crucial for effective H. pylori management.
  • Urea breath tests offer a non-invasive approach to detect H. pylori.

Purpose of the Study:

  • To explain the principle behind urea breath tests for H. pylori detection.
  • To highlight the utility of urea breath tests in monitoring eradication therapy.
  • To discuss the application of urea breath tests in studying H. pylori infection acquisition and recurrence.

Main Methods:

  • Utilizes orally administered urea labeled with either a stable isotope (13C) or a radioactive isotope (14C).
  • Measures the presence of labeled carbon dioxide (CO2) in expired breath.

Related Experiment Videos

  • Detects the urease enzyme activity of H. pylori, which metabolizes urea.

    • Main Results:

    • Positive test results indicate the presence of H. pylori in the stomach.
    • The tests accurately reflect active H. pylori infection.
    • Suitable for monitoring the efficacy of H. pylori eradication therapies.

    Conclusions:

    • Urea breath tests are reliable, non-invasive tools for diagnosing H. pylori infection.
    • [13C]-urea is recommended for children due to its non-radioactive nature.
    • [14C]-urea breath test is suitable for adults with minimal radiation exposure.