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Related Experiment Videos

Regional lymph node metastasis from cutaneous squamous cell carcinoma

D H Kraus1, J F Carew, L B Harrison

  • 1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Kraus@mskcc.org

Archives of Otolaryngology--Head & Neck Surgery
|May 30, 1998
PubMed
Summary

Survival for head and neck cutaneous squamous cell carcinoma with lymph node metastasis remains poor. Clinical neck stage is the only predictor of outcome in these patients.

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Dermatology

Background:

  • Cutaneous squamous cell carcinoma (cSCC) of the head and neck can metastasize to regional lymph nodes.
  • Metastasis to lymph nodes significantly worsens prognosis for cSCC patients.
  • Characterizing clinical presentation and prognostic factors is crucial for improving outcomes.

Purpose of the Study:

  • To identify clinical presentation features of head and neck cSCC with regional lymph node metastasis.
  • To determine prognostic factors influencing survival in these patients.
  • To evaluate the effectiveness of multimodality treatment.

Main Methods:

  • Retrospective case series of 45 patients treated between 1984 and 1995.
  • Analysis included neck dissection, parotidectomy, and postoperative radiation therapy.

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  • Kaplan-Meier survival analysis and log-rank tests were used to assess prognostic variables.

    • Main Results:

    • Patients presented with larger and deeper primary lesions compared to historical controls.
    • Overall 2- and 5-year survival rates were 33% and 22%, respectively.
    • Clinical stage of the neck was the sole significant prognostic factor (P<.01).

    Conclusions:

    • Survival for patients with regional metastasis from head and neck cSCC is poor, even with multimodality treatment.
    • Clinical staging of the neck is the most critical factor for predicting patient outcomes.
    • Further research may be needed to improve treatment strategies for this subset of patients.