Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maternal weight differences do not explain ethnic differences in biochemical screening

P K Bryant-Greenwood1, J E O'Brien, X Huang

  • 1Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Mich 48201, USA.

Fetal Diagnosis and Therapy
|May 30, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilization of direct oral anticoagulants in a Saudi tertiary hospital: a retrospective cohort study.

European review for medical and pharmacological sciences·2023
Same author

Cross-legged position versus traditional sitting position for epidural catheter insertion for labor analgesia: a non-randomized prospective study.

International journal of obstetric anesthesia·2023
Same author

Poisoning by Opium.

The Chicago medical journal·2023
Same author

Musk in Hiccough.

The Chicago medical journal·2023
Same author

Introductory to Lectures on Philosophy of Medicine, in the Spring Course of Rush Med. College, March 8, 1872.

The Chicago medical journal·2023
Same author

To Prevent Rotation in Fracture of the Femur, Etc.

The Chicago medical journal·2023
Same journal

The Solomon Technique and Extreme Preterm Birth after Laser Surgery for Twin-Twin Transfusion Syndrome.

Fetal diagnosis and therapy·2026
Same journal

Prenatal and molecular characteristics of 23 cases with Silver-Russell syndrome.

Fetal diagnosis and therapy·2026
Same journal

Consequences of selective fetal growth restriction in perinatal outcomes after fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome, based on single or dual survival.

Fetal diagnosis and therapy·2026
Same journal

Turning image labelling into knowledge: insights from fetal Left ventricular outflow tract annotation.

Fetal diagnosis and therapy·2026
Same journal

First-trimester growth rate in relation to selective fetal growth restriction in monochorionic twins.

Fetal diagnosis and therapy·2026
Same journal

Erratum.

Fetal diagnosis and therapy·2026
See all related articles

Serum marker levels for prenatal screening vary significantly across racial and ethnic groups. Separate databases for each group improve screening accuracy, as weight differences do not fully explain these variations.

Area of Science:

  • Biochemistry
  • Genetics
  • Obstetrics

Background:

  • Serum levels of alpha-fetoprotein, human chorionic gonadotropin, and estriol differ across U.S. racial/ethnic groups.
  • Previous research suggests these variations impact screening accuracy.
  • Potential confounding factors like weight differences have been proposed to explain these variations.

Purpose of the Study:

  • To investigate the impact of racial/ethnic differences on serum marker levels used in prenatal screening.
  • To determine if systematic weight differences account for observed variations in marker levels.
  • To evaluate the efficacy of using separate databases for different racial/ethnic groups to enhance screening accuracy.

Main Methods:

  • Analysis of screening results from 208,257 patients.

Related Experiment Videos

  • Comparison of serum marker levels across white, African-American, Asian, and Hispanic populations.
  • Statistical evaluation of the influence of weight differences versus racial/ethnic background on marker levels.

    • Main Results:

    • Significant variations in serum marker levels were confirmed across the four defined racial/ethnic groups.
    • Systematic weight differences were observed among the groups.
    • However, weight differences were insufficient to fully explain the magnitude of racial/ethnic variations in marker levels.

    Conclusions:

    • Racial/ethnic background is a significant factor influencing serum marker levels in prenatal screening.
    • Weight adjustment alone does not fully reconcile observed discrepancies.
    • Utilizing separate, race/ethnicity-specific databases is recommended for improved prenatal screening sensitivity and specificity.