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Effect of cytokines on anticryptococcal activity of human microglial cells
M M Lipovsky1, A E Juliana, G Gekker
1Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, Minnesota, USA.
Clinical and Diagnostic Laboratory Immunology
|May 30, 1998
Abstract:
The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.