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Updated: Aug 15, 2026

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Published on: October 19, 2014
Large granular lymphocytic leukemia: an overview
1H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
Abstract:
Large granular lymphocytes are killer cells that differentiate into natural killer and T-cell types. Neoplastic proliferation of the lineages probably involves different etiologies, producing leukemias with distinct clinical presentations and prognoses. T-large granular lymphocytic leukemia has prominent autoimmune features and may occur in association with other autoimmune diseases, particularly rheumatoid arthritis.
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