Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucosamine sulfate for osteoarthritis

C C da Camara1, G V Dowless

  • 1School of Pharmacy, Campbell University, Buies Creek, NC, USA.

The Annals of Pharmacotherapy
|June 2, 1998
PubMed
Summary

Glucosamine sulfate may offer pain relief and improved mobility for osteoarthritis patients. However, more rigorous, long-term studies are needed, especially in the US, to confirm its effectiveness and safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Twenty-first century droughts have not increasingly exacerbated fire season severity in the Brazilian Amazon.

Scientific reports·2021
Same author

Stability and compatibility of promethazine hydrochloride and dihydroergotamine mesylate in combination.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·1999
Same author

Raloxifene: a selective estrogen receptor modulator.

American family physician·1999
Same author

Treatment of wounds with procuren.

The Annals of pharmacotherapy·1993
Same author

Dantrolene for amphotericin B-induced rigors.

Archives of internal medicine·1987
Same author

Acute bacterial endocarditis due to Hemophilus parainfluenzae. Response to ceftizoxime in an ampicillin-allergic patient.

Pharmacotherapy·1987

Area of Science:

  • Rheumatology
  • Pharmacology
  • Nutritional Science

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease causing significant morbidity and disability, primarily characterized by joint pain.
  • Conventional OA treatments, including acetaminophen and NSAIDs, primarily manage pain but may have adverse effects and do not alter disease progression.
  • Glucosamine sulfate, a nutritional supplement, has emerged as a potential chondroprotective agent for OA management.

Purpose of the Study:

  • To evaluate the clinical utility of glucosamine sulfate in managing osteoarthritis symptoms.
  • To synthesize existing evidence on the efficacy and safety of glucosamine sulfate for OA treatment.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE from January 1975 to March 1997.
  • Included studies were limited to English-language trials involving human subjects diagnosed with osteoarthritis and treated with glucosamine sulfate.

Main Results:

  • Limited short-term human trials suggest glucosamine sulfate can gradually reduce joint pain and tenderness, enhancing range of motion and walking speed.
  • Consistent symptom improvement (over 50% in some cases) has been observed, with potential efficacy comparable or superior to ibuprofen.
  • This supplement has shown potential to halt or reverse OA progression without significant adverse effects.

Conclusions:

  • Glucosamine sulfate demonstrates potential for pain relief, reduced tenderness, and improved mobility in osteoarthritis patients.
  • Current evidence is largely from European and Asian studies, with a lack of supporting research from the US.
  • Deficiencies in study design, small sample sizes, and absence of long-term trials necessitate further investigation into safety, efficacy, and optimal dosing.

Related Experiment Videos