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Published on: February 3, 2012
[Characteristics of experimental models of hepatitis A in Papio hamadryas]
Abstract:
Hepatitis A (HA) was induced in 14 Papio hamadryas by strain VHA-PH isolated from this species of monkeys with spontaneous infection, strain VHA-MM isolated from Macaca mulatta, and a unique strain VHA-H3 isolated from a patient; this latter strain is pathogenic for Macaca mulatta in experiment. All infected seronegative animals developed a disease with virological, serological, biochemical, and morphological signs characteristic of human HA, but the duration of these signs manifestation varied. Virus in the feces and an increased level of SGPT were detected periodically starting from days 3-26 to 24-135, and in 4 monkeys even later (up to days 163-238). Morphologic changes in the liver, typical of acute hepatitis, were observed from days 10-46 to days 16-130. Strain VHA-H3 is less pathogenic for papios. HA models on Papio hamadryas infected with strains VHA-PH and VHA-MM can help solve many research and practical problems.
Insights
Hepatitis A (HA) was successfully induced in baboons (Papio hamadryas) using various strains. This animal model mimics human HA, offering valuable research opportunities.
Area of Science:
- * Primates and Infectious Diseases
- * Hepatitis A Virus (HAV) Research
Context:
- * Hepatitis A (HA) is a significant human pathogen.
- * Animal models are crucial for understanding viral diseases and developing interventions.
- * Papio hamadryas (baboons) are increasingly used in preclinical studies.
Purpose:
- * To establish and characterize a Hepatitis A virus (HAV) infection model in Papio hamadryas.
- * To evaluate the pathogenicity of different HAV strains in this primate model.
- * To assess the utility of this model for studying HAV pathogenesis and testing therapeutics.
Summary:
- * Fourteen Papio hamadryas were infected with HAV strains VHA-PH, VHA-MM, and VHA-H3.
- * All infected animals exhibited clinical signs, virological shedding, and biochemical changes consistent with human HA.
- * The duration of disease manifestations varied, with some animals showing prolonged viral shedding and biochemical abnormalities.
Impact:
- * The developed Papio hamadryas model provides a robust platform for studying Hepatitis A.
- * This model can facilitate research into HAV pathogenesis, immune responses, and vaccine efficacy.
- * It aids in solving practical problems related to Hepatitis A prevention and control.
