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Cyanonitrosylmetallates as potential NO-donors
J Oszajca1, G Stochel, E Wasielewska
1Department of Inorganic Chemistry, Jagiellonian University, Kraków, Poland.
Journal of Inorganic Biochemistry
|June 2, 1998
Summary
Iron complexes containing cyanide and nitric oxide ([M(CN)xNOy]n-) show pharmacological activity as nitric oxide (NO) donors. Quantum chemical calculations reveal their propensity for NO+ release, explaining their metabolic pathway.
Area of Science:
- Coordination Chemistry
- Inorganic Chemistry
- Computational Chemistry
- Pharmacology
Background:
- Nitric oxide (NO) plays crucial roles in various physiological processes.
- Development of safe and effective NO-donor molecules is of significant therapeutic interest.
- Metal-cyanido-nitrosyl complexes ([M(CN)xNOy]n-) are investigated for their potential NO-releasing properties.
Purpose of the Study:
- To evaluate the potential of [M(CN)xNOy]n- complexes (M = Cr, Mn, Fe) as nitric oxide (NO) donors.
- To investigate the pharmacological activity and metabolic pathways of these complexes.
- To elucidate the mechanism of NO+ release using theoretical methods.
Main Methods:
- Pharmacological assays were employed to assess the biological activity of the complexes.
- Theoretical semi-empirical quantum chemical calculations were performed.
- Analysis focused on nucleophilic attack susceptibility and NO+ release predisposition.
Main Results:
- Only iron-containing [M(CN)xNOy]n- complexes exhibited significant pharmacological activity.
- Quantum chemical calculations indicated a high predisposition for nucleophilic attack in iron complexes.
- This attack facilitates the release of the nitrosonium ion (NO+).
Conclusions:
- Iron [M(CN)xNOy]n- complexes are promising candidates for NO-donor applications.
- The metabolism of these complexes can be understood through the lens of NO+ donation.
- The study provides a mechanistic basis for the observed pharmacological activity.