Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current concepts of ventricular defibrillation

P S Chen1, C D Swerdlow, C Hwang

  • 1Department of Medicine, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California 90048, USA. CHENP@CSMC.EDU

Journal of Cardiovascular Electrophysiology
|June 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engagement in antenatal and HIV care among pregnant women before and after Option B+ policy implementation in South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

Emergent coherent modes in nonlinear magnonic waveguides detected at ultrahigh frequency resolution.

Nature communications·2024
Same author

Azimuthal Correlations within Exclusive Dijets with Large Momentum Transfer in Photon-Lead Collisions.

Physical review letters·2023
Same author

Magnetocaloric effect and Griffiths phase analysis in a nanocrystalline Ho<sub>2</sub>NiMnO<sub>6</sub> and Ho<sub>2</sub>CoMnO<sub>6</sub> double perovskite.

RSC advances·2023
Same author

Measurements of the associated production of a W boson and a charm quark in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2022
Same author

First Search for Exclusive Diphoton Production at High Mass with Tagged Protons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2022
Same journal

Pulsed Field Ablation Is Associated With Fewer Post-Procedural Pericardial Inflammatory Symptoms Compared With Radiofrequency Ablation.

Journal of cardiovascular electrophysiology·2026
Same journal

Single-Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same journal

Relationship Between Nonuniform Isochrone-Area in Late Activation Mapping and Arrhythmogenic Substrates Related to Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same journal

Clinical Utility of Tissue Proximity Indication With a Variable-Loop Circular Catheter for Pulmonary Vein Isolation.

Journal of cardiovascular electrophysiology·2026
Same journal

Impact of Carina Width on Re-Ablation Rate of Atrial Fibrillation After Primary Cryoballoon-Ablation.

Journal of cardiovascular electrophysiology·2026
Same journal

Mediastinal Air Entrapment During Extravascular ICD Implantation: A Preventable Cause of Elevated Shock Impedance.

Journal of cardiovascular electrophysiology·2026
See all related articles

Electrical stimulation can induce cardiac reentry and ventricular fibrillation (VF). The upper limit of vulnerability (ULV) determines defibrillation success, with shock strength and timing crucial for efficacy.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Ventricular fibrillation (VF) is a life-threatening arrhythmia.
  • Understanding the mechanisms of electrical defibrillation is critical for improving patient outcomes.

Purpose of the Study:

  • To review current concepts of ventricular defibrillation.
  • To investigate the interaction between electrical stimuli and cardiac responses.

Main Methods:

  • Studied electrical stimulus-cardiac response interaction in animal models and humans.
  • Analyzed the induction of figure-eight reentry and VF using premature stimuli (S2).
  • Investigated the role of stimulus strength, graded responses, and refractoriness in reentry formation.

Main Results:

Related Experiment Videos

  • Premature stimuli can induce figure-eight reentry and VF.
  • Beyond a critical stimulus strength, refractoriness prevents reentry formation (upper limit of vulnerability, ULV).
  • A protective zone exists post-VF induction or failed defibrillation, where stimuli can terminate reentry.

Conclusions:

  • Defibrillation shock efficacy depends on both strength and timing.
  • The ULV hypothesis explains the probabilistic nature of defibrillation.
  • Successful defibrillation requires shock field strength >= ULV throughout the ventricles.