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Dietary polyunsaturated fatty acids decrease anti-dsDNA and anti-cardiolipin antibodies production in idiotype
1School of Nutritional Sciences, The Faculty of Agriculture, The Hebrew University of Jerusalem, Israel.
Objective:
To examine the effect of diets with different polyunsaturated fatty acid contents, including linseed oil which contains 70% omega-3 fatty acids, on autoantibody production in idiotype induced mouse model of systemic lupus erythematosus (SLE).
Methods:
Five different fats were fed to mice with induced SLE and antibody titers to anti-DNA and anti-cardiolipin were determined and histological examination of kidneys were carried out.
Results:
SLE mice fed linseed oil showed lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.
Conclusion:
Use of linseed oil may attenuate the severity of SLE and this diet may be recommended for other auto-immune diseases as well.