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Related Experiment Videos

Medication take-home doses and contingency management

J M Schmitz1, H M Rhoades, R Elk

  • 1Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030, USA. jschmitz@msi66.msi.uth.tmc.edu

Experimental and Clinical Psychopharmacology
|June 3, 1998
PubMed
Summary

Contingent take-home medication doses, including methadone and fluoxetine, were studied for opiate and cocaine dependence. Increased take-home frequency improved outcomes in methadone patients and higher fluoxetine doses reduced cocaine use.

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Area of Science:

  • Addiction Medicine
  • Pharmacology
  • Behavioral Psychology

Background:

  • Opioid and cocaine dependence pose significant public health challenges.
  • Effective treatment strategies are crucial for managing substance use disorders.
  • Contingency management and medication-assisted treatment are established therapeutic approaches.

Purpose of the Study:

  • To investigate the efficacy of contingent take-home medication doses in treating opiate and cocaine dependence.
  • To evaluate the impact of varying take-home frequencies on treatment outcomes.
  • To assess the combined effect of fluoxetine and contingency management in cocaine dependence treatment.

Main Methods:

  • Two studies were conducted: one on methadone maintenance patients and another on cocaine-dependent patients receiving fluoxetine.

Related Experiment Videos

  • Patients were randomized to different baseline take-home dose frequencies.
  • A contingency management procedure was implemented, linking take-home doses to drug-free urine samples.

    • Main Results:

    • Methadone patients with more frequent baseline take-home doses showed reduced illicit drug use during contingency management.
    • In cocaine dependence treatment, the 40-mg fluoxetine group exhibited significantly less cocaine use during the contingency period.
    • Neither fluoxetine nor environmental contingencies alone were as effective as their combination.

    Conclusions:

    • Contingent take-home medication strategies can enhance treatment adherence and reduce illicit drug use in substance dependence.
    • The frequency of take-home medication distribution may influence treatment outcomes.
    • Combining pharmacotherapy (e.g., fluoxetine) with behavioral interventions (contingency management) shows promise for treating complex substance use disorders.