Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium and psychosis revisited

S J Kingsbury1, D L Garver

  • 1Department of Psychiatry, Dallas Veterans Affairs Medical Center, TX 75216, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 3, 1998
PubMed
Summary

A distinct subgroup of patients with lithium-responsive, nonaffective psychosis exists. These individuals show unique genetic, symptomatic, and biological differences, suggesting a separate disorder that may benefit from lithium treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mentoring psychiatric trainees' first paper for publication.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
Same author

Meta-analysis of 32 genome-wide linkage studies of schizophrenia.

Molecular psychiatry·2009
Same author

CSF homocysteine is not elevated in schizophrenia.

Journal of neural transmission (Vienna, Austria : 1996)·2005
Same author

Schizophrenia spectrum disorders: an autosomal-wide scan in multiplex pedigrees.

Schizophrenia research·2001
Same author

Considerations in choosing an antidepressant.

Psychiatric services (Washington, D.C.)·2001
Same author

Characterization of human cleaved N-CAM and association with schizophrenia.

Experimental neurology·2001

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Psychoses are heterogeneous, complicating treatment.
  • Differential medication response may delineate distinct psychotic subgroups.
  • Lithium has shown efficacy in specific patient groups.

Purpose of the Study:

  • To review evidence supporting a distinct subgroup of lithium-responsive, nonaffective psychosis.
  • To explore the characteristics and potential distinctiveness of this subgroup.
  • To identify areas for future research in lithium-responsive psychoses.

Main Methods:

  • Literature review of studies on lithium response in nonaffective psychosis.
  • Analysis of family history, prodromal adjustment, symptom presentation, and biological markers.

Related Experiment Videos

  • Examination of challenge test results and preliminary etiological associations.

    • Main Results:

    • A subgroup with lithium-responsive, nonaffective psychosis exhibits unique features.
    • This subgroup shows less genetic loading, fewer negative symptoms, and distinct in vitro lithium ratios.
    • Physostigmine challenge tests indicated greater symptom reduction, unlike apomorphine tests.

    Conclusions:

    • Evidence supports lithium-responsive nonaffective psychosis as a distinct entity.
    • This subgroup may represent a phenocopy of other psychotic disorders.
    • Further research is crucial to confirm its status and optimize treatment strategies.