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Bone density measurement in major depression

J D Amsterdam1, M B Hooper

  • 1Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 3, 1998
PubMed
Summary
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Depression is linked to high cortisol, potentially affecting bone density. This study found no significant difference in bone mineral density between depressed patients and healthy controls, even with hypercortisoluria.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Bone Metabolism

Background:

  • Depression is associated with hyperactivity of the hypothalamic-pituitary-adrenocortical axis, leading to excessive cortisol secretion (hypercortisolemia).
  • Hypercortisolemia may impact bone metabolism, with some studies suggesting lower bone density in depressed individuals with elevated cortisol levels.

Purpose of the Study:

  • To investigate bone mineral density (BMD) in patients with depression, comparing those with and without hypercortisoluria to healthy controls.

Main Methods:

  • Bone mineral density (BMD) was measured in the lumbar vertebrae (L1-L4) of 6 depressed patients and 5 healthy controls using dual energy radiographic absorptometry (DEXA).
  • Patients were categorized into those with and without hypercortisoluria.

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Main Results:

  • No significant differences in mean BMD were found between the depressed patients and the healthy controls.
  • BMD did not differ between depressed patients with and without hypercortisoluria.

Conclusions:

  • This study did not find evidence that depression, with or without hypercortisoluria, is associated with altered lumbar BMD.
  • Further research is needed to fully understand the relationship between depression, cortisol levels, and bone health.