Effects of thioperamide on locomotor activity and on memory processes

1. Rats were tested in an open field. Thioperamide given i.p. 30 minutes before the tests produced an increase of locomotor activity at 2 mg/kg and no behavioral effect at 5 mg/kg. 2. The repetition of the open field tests caused a reduction of ambulation in three successive tests. This effect was increased by thioperamide 2 and 5 mg/kg given after the tests, suggesting that this compound improved memory consolidation.