Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The decrease of liver LDL receptor mRNA during fasting is related to the decrease in serum T3

A M van der Wal1, O Bakker, W M Wiersinga

  • 1Department of Endocrinology, Academical Medical Center, University of Amsterdam, The Netherlands.

The International Journal of Biochemistry & Cell Biology
|June 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Observable Movement Quality scale for patients with low back pain (OMQ-LBP): validity and reliability in a primary care setting of physical therapy.

BMC musculoskeletal disorders·2023
Same author

The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy.

European journal of endocrinology·2021
Same author

Asymmetry indicates more severe and active disease in Graves' orbitopathy: results from a prospective cross-sectional multicentre study.

Journal of endocrinological investigation·2020
Same author

Antithyroid drug treatment for Graves' disease: baseline predictive models of relapse after treatment for a patient-tailored management.

Journal of endocrinological investigation·2018
Same author

Thyroid disease symptoms during early pregnancy do not identify women with thyroid hypofunction that should be treated.

Clinical endocrinology·2017
Same author

Graves' orbitopathy as a rare disease in Europe: a European Group on Graves' Orbitopathy (EUGOGO) position statement.

Orphanet journal of rare diseases·2017

Fasting lowers thyroid hormones (T3 and T4) and decreases liver LDL receptor expression, leading to increased LDL cholesterol. Maintaining T3 levels prevents this rise, suggesting a link between thyroid function and cholesterol during fasting.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Lipid Metabolism

Background:

  • Fasting is known to alter thyroid hormone levels and lipid profiles.
  • A potential link between fasting-induced hypothyroidism and increased LDL cholesterol has been proposed.

Purpose of the Study:

  • To investigate the relationship between changes in thyroid hormones and cholesterol metabolism during fasting.
  • To determine if a hypothyroid-like state induced by fasting contributes to elevated LDL cholesterol.

Main Methods:

  • Rats were fasted for varying durations (0-48 hours).
  • Measurements included serum thyroid hormones (T3, T4, TSH), liver enzyme mRNA expression (5'-deiodinase, LDL receptor, HMG CoA reductase, cholesterol 7 alpha-hydroxylase), and plasma LDL cholesterol.
  • T3 supplementation was administered to some fasted rats.

Related Experiment Videos

Main Results:

  • Fasting decreased liver 5'-deiodinase mRNA, serum T3, and serum T4.
  • Plasma LDL cholesterol increased after 24 hours of fasting.
  • Decreased liver LDL receptor mRNA expression preceded the rise in LDL cholesterol and correlated with serum T3 levels.
  • T3 supplementation prevented the decrease in LDL receptor mRNA during fasting.

Conclusions:

  • Fasting induces a hypothyroid-like condition, potentially due to inhibited hepatic T4 to T3 conversion.
  • Fasting increases plasma LDL cholesterol, primarily mediated by reduced hepatic LDL receptor gene expression linked to lower serum T3 levels.