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Updated: Jul 27, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Asthma associated with gastroesophageal reflux]
J E González Morales1, L Leal de Hernández, D González Spencer
1Clínica de Asma del servicio de neumología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, NL, México.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 3, 1998
Summary
This study found that treating gastroesophageal reflux (GER) with omeprazole and cisapride significantly improved poorly controlled asthma in most patients. Long-term management requires ongoing antireflux measures for sustained symptom relief.
Area of Science:
- Pulmonology
- Gastroenterology
- Clinical Medicine
Background:
- Poorly controllable asthma is a significant clinical challenge.
- Gastroesophageal reflux (GER) is a potential contributing factor in difficult-to-manage asthma.
- Understanding the link between GER and asthma is crucial for effective treatment.
Purpose of the Study:
- To investigate the association between gastroesophageal reflux (GER) and poorly controllable asthma.
- To evaluate the efficacy of antireflux therapy in patients with difficult-to-manage asthma.
Main Methods:
- A prospective clinical trial involving 28 patients with poorly controlled asthma and negative atopic indicators.
- Patients underwent comprehensive medical evaluations, including allergy testing, spirometry, and imaging.
- Treatment involved 8 weeks of omeprazole and cisapride for antireflux therapy.
Main Results:
- 85.7% of patients experienced complete improvement in asthma symptoms.
- 10.7% showed moderate improvement, and 3.6% had no improvement.
- Three patients ultimately required antireflux surgery.
Conclusions:
- Antireflux therapy, including omeprazole and cisapride, is highly effective in managing poorly controllable asthma associated with GER.
- Sustained symptom control necessitates long-term adherence to antireflux measures, making them a lifestyle change.
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