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Related Experiment Videos

[Modulators of leukocytic functions]

P Nguyen1, M Broussas, N Hézard

  • 1Laboratoire central d'Hématologie, CHU Robert Debré, Reims.

Journal Des Maladies Vasculaires
|June 3, 1998
PubMed
Summary
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Polymorphonuclear neutrophils and monocytes contribute to vascular diseases. Targeting leukocyte hyperactivity with drugs like pentoxifylline shows promise for treating conditions such as peripheral artery disease.

Area of Science:

  • Immunology
  • Vascular Biology
  • Pharmacology

Context:

  • Polymorphonuclear neutrophils (PMN) and monocytes are implicated in vascular diseases, including ischemia-reperfusion syndrome and myocardial infarction.
  • In humans, elevated oxygen radicals, PMN elastase, and monocyte tissue factor (TF) are observed in coronary artery disease, peripheral artery disease, and diabetes.

Purpose:

  • To explore the rationale for pharmacologically modulating leukocyte hyperactivity in vascular diseases.
  • To review existing and potential therapeutic targets for controlling leukocyte activation.

Summary:

  • Animal models and human studies confirm the role of leukocytes in vascular pathology.
  • Several drugs, including pentoxifylline, gingkolides, aspirin, and alpha-tocopherol, demonstrate potential in modulating leukocyte functions like adhesion, radical production, and TF formation.

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  • Cytokines such as TNF, IL-1, IL-4, and IL-10 are also identified as targets for controlling leukocyte activation.

    • Impact:

    • Pharmacological interventions targeting leukocyte hyperactivity represent a promising, albeit preliminary, strategy for managing vascular diseases.
    • Further research is needed to fully elucidate the therapeutic potential of these agents in clinical settings.