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Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
E X Souto1, M de L Chauffaile, J E Moncau
1Department of Hematology, Faculdade de Medicina de Botucatu, Escola Paulista de Medicina/UNIFESP, São Paulo, Brazil.
Objective:
To evaluate the score systems of Cassano and Sanz and suggest a new one.
Design:
Case series.
Location:
Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu.
Participants:
59 patients diagnosed from 1979 to 1992.
Intervention:
Evaluation of clinical-laboratorial data.
Measurement:
Statistical comparison, uni and multivariate analysis and actuarial survival curves.
Results:
Cassano's system divided the patients into high and low risk (p = 0.0966) while Sanz's gave high, intermediate and low risk (p = 0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p = 0.004) and Hb (p = 0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p = 0.0038).
Conclusions:
Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.