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Induced abortion in the first trimester of pregnancy and risk of miscarriage
F Parazzini1, L Chatenoud, L Tozzi
1Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Objective:
To analyse the relation between induced abortion and risk of subsequent miscarriage.
Design:
Case-control study conducted between February 1990 and May 1995.
Participants:
Case group included 782 women (median age 32 years, range 14-46) admitted for spontaneous abortion (within the 12th week of gestation) to a network of obstetric departments in the greater Milan area. The control group was recruited among women who gave birth at term (> 37 weeks of gestation) to healthy infants on randomly selected days at the hospitals where cases had been identified. A total of 1543 controls (median age 30 years, range 14-45) were interviewed.
Results:
A total of 102 cases (13%) and 181 controls (12%) reported one or more induced abortions. No clear relation emerged between miscarriage and induced abortions. In comparison with women reporting no induced abortion the odds ratio (OR) for miscarriage were 1.1 (95% CI 0.8-1.4) in women reporting one induced abortion and 0.9 (95% CI 0.4-1.8) in women reporting two or more. Likewise, there was no association between time since last and age at first induced abortion and risk of miscarriage.
Conclusions:
This study did not find any strong association between induced and spontaneous abortion.