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Study of left ventricular bypass using Wankel type semipulsatile blood pump
N Mitsui1, S Fukunaga, T Sueda
1First Department of Surgery, Hiroshima University School of Medicine, Japan.
Artificial Organs
|June 3, 1998
Summary
This study shows that Wankel-type semipulsatile assist devices improve hemodynamics in heart failure by increasing mean aortic pressure and decreasing pulsatility. These findings support their use in clinical settings.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
Background:
- Left ventricular assistance is crucial for managing heart failure.
- Semipulsatile blood pumps offer a potential therapeutic option.
Purpose of the Study:
- To investigate the hemodynamic effects of Wankel-type semipulsatile left ventricular assistance.
- To evaluate the device's performance under simulated heart failure conditions.
Main Methods:
- Computer simulation of the circulatory system with a semipulsatile blood pump.
- Animal experiment using a Wankel-type blood pump in a calf model.
- Simulation of left heart failure by reducing left ventricular compliance.
Main Results:
- Increased assist flow raised mean aortic pressure (AoP), tension time index (TTI), and diastolic pressure time index (DPTI) during heart failure.
- Cardiac output, pulse pressure (PP), and pulsatility indicator (PI) decreased with increased assist flow.
- Animal experiments confirmed reduced AoP pulsatility, PP, and PI, aligning with simulation predictions.
Conclusions:
- Wankel-type semipulsatile assist devices can favorably alter hemodynamics in simulated heart failure.
- The device effectively reduces pulsatility while maintaining or increasing mean aortic pressure.
- Numerical simulations accurately predict the hemodynamic outcomes observed in animal experiments.