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Related Experiment Videos

Autonomic function in children with type 1 diabetes mellitus

H Tanaka1, L Hyllienmark, O Thulesius

  • 1Department of Paediatrics, Osaka Medical College, Japan.

Diabetic Medicine : a Journal of the British Diabetic Association
|June 3, 1998
PubMed
Summary
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Autonomic function in Type 1 diabetes is largely preserved in youth, with no significant vagal impairment. However, beat-to-beat blood pressure variation may be reduced, correlating with metabolic control.

Area of Science:

  • Pediatric Endocrinology
  • Autonomic Neuroscience
  • Cardiovascular Physiology

Background:

  • Type 1 diabetes mellitus (T1DM) can affect autonomic nervous system function.
  • Autonomic dysfunction in T1DM is typically assessed using cardiovascular reflex tests.
  • Limited data exists on autonomic function in asymptomatic children and young adults with T1DM.

Purpose of the Study:

  • To investigate autonomic function in children and young adults with T1DM.
  • To compare autonomic function between T1DM patients and healthy controls.
  • To assess the correlation between autonomic function and metabolic control in T1DM.

Main Methods:

  • Evaluated 58 T1DM patients (aged 7-22) and 74 healthy controls.
  • Utilized power spectral analysis of blood pressure and heart rate.

Related Experiment Videos

  • Performed deep breathing, Valsalva maneuver, and standing tests.

    • Main Results:

    • No significant differences in Valsalva or deep breathing tests between groups.
    • Heart rate variation was lower in T1DM patients, but spectral analysis showed no significant decrease.
    • Beat-to-beat blood pressure fluctuation was significantly lower in T1DM patients and correlated with HbA1c.

    Conclusions:

    • Vagal nerve involvement in T1DM is uncommon in this age group.
    • Beat-to-beat blood pressure variation is more likely to be affected in young T1DM patients.
    • Autonomic function, particularly blood pressure variability, may be an early indicator of T1DM complications.