Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlactatemia during acute severe asthma

A Rabbat1, J P Laaban, A Boussairi

  • 1Service de Pneumologie et Réanimation Médicale, Hôtel-Dieu de Paris, France.

Intensive Care Medicine
|June 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Aspergillus-related respiratory conditions and COPD: Diagnostic challenges].

Revue des maladies respiratoires·2020
Same author

[Multidisciplinary approach of ventilated necrotizing pneumonia].

Reanimation : journal de la Societe de reanimation de langue francaise·2020
Same author

[Corticosteroids in community acquired pneumonia: Where are we in 2018?]

Revue des maladies respiratoires·2018
Same author

Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs).

Annals of intensive care·2018
Same author

Management of acute exacerbations of chronic obstructive pulmonary disease (COPD). Guidelines from the Société de pneumologie de langue française (summary).

Revue des maladies respiratoires·2017
Same author

[When to start, how to manage and when to stop non-invasive ventilation during acute COPD exacerbation?]

Revue des maladies respiratoires·2017
Same journal

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy.

Intensive care medicine·2026
Same journal

Prehospital airway and ventilatory management: a collaborative and narrative review.

Intensive care medicine·2026
Same journal

Rapid coma with bilateral basal ganglia involvement.

Intensive care medicine·2026
Same journal

From size to function: moving beyond body mass index to frailty and central adiposity phenotypes.

Intensive care medicine·2026
Same journal

Effects of a clinical metagenomics intervention on clinical outcomes, healthcare costs, and health-related quality of life in patients with sepsis or septic shock: results of the randomized-controlled DigiSep trial.

Intensive care medicine·2026
Same journal

Hypercalcemia in intensive care unit: pathophysiological mechanisms and clinical implications.

Intensive care medicine·2026
See all related articles

Arterial hyperlactatemia is common in acute severe asthma (ASA) upon ICU admission and consistently develops during treatment. However, elevated lactate levels appear to have no prognostic value in ASA patients, as none required mechanical ventilation.

Area of Science:

  • Pulmonology
  • Critical Care Medicine
  • Biochemistry

Background:

  • Acute severe asthma (ASA) is a critical condition requiring intensive care.
  • Arterial hyperlactatemia, an elevation in blood lactate, is a known indicator of metabolic stress.
  • The role of lactate levels in predicting outcomes for ASA patients is not well-defined.

Purpose of the Study:

  • To investigate arterial lactate levels in patients with ASA during intensive care unit (ICU) treatment.
  • To determine the prognostic significance of arterial hyperlactatemia in ASA.

Main Methods:

  • A prospective study was conducted in a university hospital's respiratory ICU.
  • 29 non-intubated ASA patients with severe airflow limitation were enrolled.
  • Arterial lactate levels were serially measured during the first 24 hours of standardized treatment.

Related Experiment Videos

Main Results:

  • 59% of ASA patients presented with arterial hyperlactatemia (lactate > 2 mmol/l) upon ICU admission.
  • All patients experienced a transient, significant increase in arterial lactate during treatment, peaking at 7.72 mmol/l.
  • No correlation was found between initial lactate levels and various clinical or biochemical parameters, nor did initial or delayed hyperlactatemia correlate with the need for mechanical ventilation.

Conclusions:

  • Arterial hyperlactatemia is frequently observed on admission and during treatment of ASA.
  • Neither initial nor delayed hyperlactatemia appears to hold prognostic value in ASA patients managed in the ICU.
  • Further research is needed to understand the impact of asthma therapies on lactate metabolism.