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Primary central nervous system lymphoma in a child with acute B-cell lymphoblastic leukaemia: consecutive
S C Buckingham1, E Benaim, J T Sandlund
1Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
Abstract:
Primary central nervous system lymphoma (PCNSL), observed among immunocompromised AIDS patients, has not been reported during chemotherapy for acute lymphoblastic leukaemia (ALL). We report a case of PCNSL occurring in a child receiving intensive multiagent chemotherapy for B-cell ALL. In situ hybridization studies demonstrated Epstein-Barr virus genome in both tumours, suggesting a possible link between the two diseases. The clinical response of the PCNSL to conservative therapy highlights the importance of accurately diagnosing such EBV-related disorders, especially in patients where immune compromise can be reversed.