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Modeling bronchial circulation with application to soluble gas exchange: description and sensitivity analysis
T D Bui1, D Dabdub, S C George
1Department of Chemical and Biochemical Engineering and Materials Science, University of California, Irvine, California 92697-2575, USA.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 11, 1998
Summary
Ethanol exchange in airways depends on blood flow, with contributions from bronchial and pulmonary circulation. Model analysis reveals tissue thickness is more critical than bronchial circulation for exhaled ethanol and temperature.
Area of Science:
- Respiratory Physiology
- Gas Exchange Dynamics
- Mathematical Modeling
Background:
- Inert gas exchange in the canine trachea is limited by diffusion and perfusion.
- Ethanol, with high blood solubility, may have airway exchange influenced by bronchial circulation.
Purpose of the Study:
- To test the hypothesis that ethanol exchange in airways depends on bronchial circulation.
- To investigate the impact of bronchial circulation dynamics on soluble gas exchange in the airways.
Main Methods:
- Incorporated bronchial circulation dynamics into an existing airway exchange model.
- Performed sensitivity analysis using Latin hypercube sampling.
- Validated the model against experimental ethanol exhalation profiles and temperature data.
Main Results:
- The model accurately predicted ethanol exhalation profiles (R2 = 0.991) and end-exhaled temperature.
- Predicted contributions to exhaled ethanol: 27% mucosa/submucosa, 29% bronchial circulation, 44% external tissue (pulmonary circulation).
- Model outputs were insensitive to bronchial circulation parameters but sensitive to tissue thickness.
Conclusions:
- Both bronchial and pulmonary circulations influence soluble gas exchange in the conducting airway tree.
- Tissue thickness between core body conditions and bronchial smooth muscle is a critical factor in airway gas exchange.