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Chronic thyroiditis: diffuse uptake of FDG at PET

S Yasuda1, A Shohtsu, M Ide

  • 1HIMEDIC Imaging Center at Lake Yamanaka, Yamanashi, Japan.

Radiology
|June 4, 1998
PubMed
Summary
This summary is machine-generated.

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Diffuse 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake in the thyroid is more common in women and may indicate chronic thyroiditis. This finding can be incidentally detected during positron emission tomography (PET) scans.

Area of Science:

  • Nuclear medicine
  • Endocrinology
  • Radiology

Background:

  • Diffuse thyroidal uptake of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) on positron emission tomography (PET) scans is not well-characterized.
  • Understanding its prevalence and clinical significance is crucial for accurate interpretation of PET imaging.

Purpose of the Study:

  • To determine the frequency and clinical importance of diffuse FDG uptake in the thyroid gland.
  • To investigate the association between diffuse thyroidal FDG uptake and thyroid function and autoimmunity.

Main Methods:

  • Whole-body PET scans were performed on 1,102 healthy subjects.
  • Thyroidal FDG uptake was evaluated, and thyroid function tests (serum free thyroxine, thyrotropin) were measured in subjects with and without uptake.
  • Antithyroid antibodies and ultrasonography (US) findings were assessed to evaluate for thyroid abnormalities.

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Main Results:

  • Diffuse FDG uptake was observed in 36 subjects (3.3%), with a significantly higher prevalence in women (P < .01).
  • Most subjects with uptake were euthyroid (35/36), with one case of hypothyroidism.
  • Positive antithyroid antibodies and US abnormalities suggestive of chronic thyroiditis were significantly more frequent in subjects with diffuse thyroidal FDG uptake compared to controls (P < .01).

Conclusions:

  • Diffuse thyroidal FDG uptake may serve as an indicator of chronic thyroiditis.
  • The prevalence of this finding is not low, and it can be incidentally detected during FDG PET imaging.
  • Further investigation may be warranted to elucidate the specific implications of diffuse thyroidal FDG uptake.