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Related Experiment Videos

Topical anthralin therapy for refractory nail psoriasis

T Yamamoto1, I Katayama, K Nishioka

  • 1Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.

The Journal of Dermatology
|June 4, 1998
PubMed
Summary

Topical anthralin therapy effectively treated nail psoriasis in 60% of patients within five months. This treatment showed significant improvement for onycholysis and pachyonychia, offering a useful option for refractory cases.

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Area of Science:

  • Dermatology
  • Dermatopathology

Background:

  • Psoriasis frequently affects nails, yet effective treatments remain limited.
  • Nail psoriasis significantly impacts patient quality of life.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical anthralin therapy for nail psoriasis.
  • To assess treatment response in patients with psoriasis vulgaris and nail involvement.

Main Methods:

  • Twenty patients with nail psoriasis received daily application of 0.4-2.0% anthralin in petrolatum to the nail bed.
  • Treatment duration was five months, with triethanolamine cream used to mitigate pigmentation.
  • Clinical outcomes including onycholysis, pachyonychia, and pitting were assessed.

Main Results:

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  • Sixty percent (12/20) of patients demonstrated moderate to obvious improvement.
  • Twenty percent (4/20) of patients showed no response to the therapy.
  • Clinical improvements were observed in onycholysis and pachyonychia; pitting decreased in some cases.

Conclusions:

  • Topical anthralin therapy is an effective treatment for nail psoriasis.
  • This regimen is a potentially useful option for managing refractory nail psoriasis.
  • Reversible nail plate pigmentation was the primary side effect observed.