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Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor beta locus
K Tsukamoto1, S Inoue, T Hosoi
1Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan.
Journal of Human Genetics
|June 4, 1998
Abstract:
A gene for a second type of human estrogen receptor, the estrogen receptor beta (ESR beta), was recently identified. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human estrogen receptor beta gene. High heterozygosity (0.93) makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems; calcium metabolism; and breast, uterine, and ovarian cancers.