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Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP)

I Watanabe¹, K Tsukamoto, T Shiba

¹Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.

Journal of Human Genetics

|June 4, 1998

Abstract:

Matrix Gla protein (MGP) is an 84-residue, vitamin K-dependent protein expressed by chondrocytes and vascular smooth muscle cells, and is a potent regulator of calcium deposition in cartilage and arterial wall. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human MGP gene. This polymorphism will be useful in genetic studies of arteriosclerosis and osteoporosis.

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