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Systemic diclofenac sodium to maintain mydriasis during phacoemulsification
1Department of Ophthalmology, Southern General Hospital NHS Trust, Glasgow, Scotland.
Journal of Cataract and Refractive Surgery
|June 4, 1998
Summary
Oral diclofenac sodium did not significantly affect pupil dilation during cataract surgery. Pupil size remained stable in both the diclofenac and control groups, with minimal regression observed.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Maintaining adequate pupil dilation (mydriasis) is crucial for successful phacoemulsification cataract surgery.
- Systemic medications can potentially influence intraoperative pupil dynamics.
Purpose of the Study:
- To investigate the effect of oral diclofenac sodium on mydriasis maintenance during phacoemulsification.
- To compare pupil diameter regression rates between patients receiving diclofenac and a control group.
Main Methods:
- Prospective, randomized controlled study involving 100 patients undergoing cataract surgery.
- Standardized mydriatic regimen administered to all participants.
- Diclofenac group (n=48) received 50 mg oral diclofenac sodium 1 hour pre-surgery; control group (n=52) did not.
- Phacoemulsification performed by a masked surgeon; pupil diameter measured at five intraoperative stages.
Main Results:
- Mean pupil diameter was slightly larger in the diclofenac group, but this difference was not statistically significant.
- Pupil diameter regression slopes were nearly identical between groups during the initial surgical stages.
- A minor reversal in mydriasis occurred in both groups later in the procedure, with overall small regression rates.
Conclusions:
- Systemic administration of 50 mg oral diclofenac sodium does not significantly inhibit miosis during phacoemulsification.
- The drug did not substantially alter pupil diameter regression rates compared to a control group.