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Eosinophil-induced chronic hepatitis

Y J Kim1, J H Jeon, N S Kim

  • 1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea.

Journal of Korean Medical Science
|June 4, 1998
PubMed
Summary
This summary is machine-generated.

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A rare case of chronic hepatitis with hypereosinophilia in an infant was linked to parasitic infection. Anthelmintic treatment improved liver function and eosinophil counts but not cardiopulmonary symptoms.

Area of Science:

  • Hepatology
  • Pediatrics
  • Parasitology

Background:

  • Chronic hepatitis with hypereosinophilia is exceptionally rare.
  • Infantile presentations are seldom documented, posing diagnostic challenges.

Observation:

  • A 7-month-old male infant presented with fever, cough, vomiting, and hepatomegaly.
  • Peripheral blood eosinophil count reached 21,500/mm3 (49% of WBC).
  • History of contact with a pigsty suggested potential parasitic exposure.

Findings:

  • Liver pathology revealed severe porto-periportal necroinflammation with marked eosinophilic infiltration, giant cell transformation, and hepatocyte ballooning.
  • Bone marrow showed eosinophilia and a decreased myeloid series.
  • Echocardiography revealed pericardial effusion and bilateral pulmonary consolidation.

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Implications:

  • Corticosteroid therapy exacerbated symptoms, indicating a non-allergic or adverse reaction.
  • Anthelmintic treatment effectively normalized eosinophil counts and liver enzymes.
  • Persistent cardiopulmonary manifestations highlight the potential for severe, long-term sequelae from parasitic infections in infants.